Bioavailability and pharmacokinetics of florfenicol in healthy foals

Research Abstract

Bioavailability and pharmacokinetics of florfenicol in healthy foals M.A. Tohamy and Abeer M. Radi Pharmacology Department, Faculty of Veterinary Medicine, Beni-suef University, Egypt Summary The Pharmacokinetic profile of florfenicol was studied in foals following a single intravenous and intramuscular administration of 20 mg kg-1 b.wt. After intravenous injection, the serum florfenicol concentration time course obeys two-compartment open model with distribution (t0.5(α)) and elimination (t0.5(β)) half lives of 0.194 and 5.208 h., respectively. Total body clearance (ClB) and steady state volume of distribution (Vdss) were 0.254 L kg-1 h-1 and 1.907 L kg-1., respectively. Following intramuscular administration the mean peak serum concentration (Cmax) was 4.709 µg ml-1 achieved after maximum time (tmax) of 1.50 hour post-injection. The mean values for absorption and elimination half-lives (t0.5(ab) and t0.5(el)) and MRT were 0.292, 7.20 and 10.81 h., respectively. The systemic bioavailability after intramuscular administration was 73.489 % and the serum protein binding was 16.32 %.

Research Keywords

Bioavailability - florfenicol